In November 2018 the Santa Fe Institute hosted a two‐day workshop titled Developmental Bias and Evolution, funded by a grant from the John Templeton Foundation. Involving 34 participants and 22 talks, the workshop covered a wide range of approaches toward the study of bias exerted by developmental systems in the production of phenotypic variation, the impact such bias might have on evolutionary dynamics, and the methods that exist to assess the nature and consequences of this impact. Talks included historical retrospectives, philosophical examinations, and a great diversity of empirical treatments of the subject. Significant discussion and debate followed each presentation, and creative tensions emerged around key issues that characterize the diversity of perceptions of what, exactly, constitutes bias in developmental systems, when or how such bias may be evolutionarily relevant, and at the most basic level, whether the concept of developmental bias is itself useful in fueling a productive research program. This special issue is meant to capture this diversity of viewpoints, and to provide a collection of perspectives that will inform and motivate the next round of research, and the next generatines, yet coalesce around a shared understanding that developmental bias shapes, and is shaped by evolution in ways that have the potential to greatly impact our understanding of why and how developmental evolution unfolds as it does.